Correction to lepirudin dosage in table 1 of ‘Direct Thrombin Inhibitors’
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چکیده
منابع مشابه
Effect of direct thrombin inhibitors, bivalirudin, lepirudin, and argatroban, on prothrombin time and INR values.
Direct thrombin inhibitors (DTIs) represent a new class of promising anticoagulation agents. The DTIs frequently are used to provide initial anticoagulation, with long-term therapy requiring eventual transition to coumarins. Unfortunately, DTIs not only prolong the activated partial thromboplastin time but also can affect international normalized ratio (INR) values. We approximated the DTI effe...
متن کاملDevelopment of Direct Thrombin Inhibitors
Anticoagulants are the cornerstone of therapy for conditions associated with arterial and venous thrombosis. Direct thrombin inhibitors (DTIs) are anticoagulants that bind to thrombin and block its enzymatic activity. The bivalent parenteral DTIs hirudin and bivalirudin were based on the observation that the salivary extracts of medicinal leeches prevented blood from clotting. Key events that f...
متن کاملDirect thrombin inhibitors in cardiovascular medicine.
Currently used antithrombotics such as heparin have a number of potential limitations that may be overcome by the new class of agents that directly inhibit thrombin. These agents variously block the active catalytic and/or the anion binding exosites of the thrombin molecule and are potent and specific inhibitors of thrombin's many biological actions, as demonstrated by in vitro and animal model...
متن کاملDirect thrombin inhibitors in atrial fibrillation reloaded.
Inhibition of plasmatic coagulation is the key therapeutic principle for thromboprophylaxis and stroke prevention in atrial fibrillation. The coagulation cascade is initiated by contact of tissue factor (TF) with circulating factor (F) VIIa, resulting in the formation of the TF–VIIa complex. The latter catalyses the conversion of FIX to IXa and FX to Xa. Together with FVa, phospholipids, and ca...
متن کاملClinical results with direct thrombin inhibitors.
Direct thrombin inhibitors inactivate thrombin without the need for antithrombin and some inactivate not only thrombin but also fibrin-bound thrombin. Hirudin has been shown to be more effective than low-dose unfractionated heparin and low molecular weight heparin for the prevention of deep vein thrombosis in high-risk orthopaedic patients. Major studies are assessing the value of direct thromb...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2011
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.2011.04078.x